Publications

REISSIG, F., K. ZACHSLER, Z. NOVÝ, M. PETŘÍK, K. BENDOVÁ, D. KURFÜRSTOVÁ, J. BOUCHAL, M. ĹUDIK, F. BRANDT, K. KOPKA, M. KHOYLOU, H. PIETZSCH, M. HAJDÚCH a C. MAMAT. Modulating the pharmacokinetic profile of Actinium-225-labeled macropa-derived radioconjugates by dual targeting of PSMA and albumin. Theranostics. 2022, 12 (17), 7203-7215. ISSN: 1838-7640. IF: 11.6. PMID: 

KVAKOVA, K., M. ONDRA, J. SCHIMER, M. PETŘÍK, Z. NOVÝ, H. RAABOVA, M. HAJDÚCH a P. CIGLER. Visualization of Sentinel Lymph Nodes with Mannosylated Fluorescent Nanodiamonds. Advanced Functional Materials. 2022, 32 (23), 2109960. ISSN: 1616-301X. IF: 18.808. PMID: 

CENTORAME, A., D. DUMUT, M. YOUSSEF, M. ONDRA, I. KIANICKA, J. SHAH, R. PAUN, T. OŽDIAN, J. HANRAHAN, E. GUSEV, B. PETROF, M. HAJDÚCH, R. PISLARIU, J. DE SANCTIS a D. RADZIOCH. Treatment With LAU-7b Complements CFTR Modulator Therapy by Improving Lung Physiology and Normalizing Lipid Imbalance Associated With CF Lung Disease. Frontiers inPharmacology. 2022, 13 876842. ISSN: 1664-3224. IF: 5.810. PMID: 

HRUBÁ, L., P. POLISHCHUK, V. DAS, M. HAJDÚCH a P. DŽUBÁK. An identification of MARK inhibitors using high throughput MALDI-TOF mass spectrometry. Biomedicine & Pharmacotherapy. 2022, 146 112549. ISSN: 0753-3322. IF: 6.530. PMID: 34923338 

ANNADURAI, N., L. MALINA, J. MALOHLAVA, M. HAJDÚCH a V. DAS. Tau R2 and R3 are essential regions for tau aggregation, seeding and propagation. Biochimie. 2022, 200 79-86. ISSN: 0300-9084. IF: 4.079. PMID: 35623497 

ZELJKOVIC, S., E. SCHADICH, P. DŽUBÁK, M. HAJDÚCH a P. TARKOWSKI. Antiviral Activity of Selected Lamiaceae Essential Oils and Their Monoterpenes Against SARS-Cov-2. Frontiers in Pharmacology. 2022, 13, 893634, ISSN 1663-9812, IF: 5.811, PMID: 35586050

SLAVÍK, H., V. BALIK, F. KOKAS, R. SLAVKOVSKÝ, J. VRBKOVÁ, A. ŘEHULKOVÁ, T. LAUSOVÁ, J. EHRMANN, S. GURSKÁ, I. ÜBERALL, M. HAJDÚCH a J. SROVNAL. Transcriptomic Profiling Revealed Lnc-GOLGA6A-1 as a Novel Prognostic Biomarker of Meningioma Recurrence. Neurosurgery. 2022, 91 (2), 360-369. ISSN: 0148-396X . IF: 4.654. PMID: 35551164 

KUDLOVÁ, N., J. DE SANCTIS a M. HAJDÚCH. Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs. International Journal of Molecular Sciences. 2022, 23 (8), 4168. ISSN: 1422-0067. IF: 5.924. PMID: 35456986 

MACEČKOVÁ, Z., A. KUBÍČKOVÁ, J. DE SANCTIS a M. HAJDÚCH. Effect of Glucocorticosteroids in Diamond-Blackfan Anaemia: Maybe Not as Elusive as It Seems. International Journal of Molecular Sciences. 2022, 8 (23), 3. ISSN: 1422-0067. IF: 5.924. PMID: 35163808 

JURÁŠEK, M., J. ŘEHULKA, L. HRUBÁ, A. IVANOVA (NIKONENKO), S. GURSKÁ, O. MOKSHYNA, P. TROUSIL, K. HUML, P. POLISHCHUK, M. HAJDÚCH, P. DRAŠAR a P. DŽUBÁK. Triazole-based estradiol dimers prepared via CuAAC from 17α-ethinyl estradiol with five-atom linkers causing G2/M arrest and tubulin inhibition. Bioorganic Chemistry. 2022, - -. ISSN: 0045-2068. IF: 5.307. PMID: 36592487 

VIDLAŘOVÁ, M., E. BERTA, P. PRASIL, A. PROKOPOVÁ, S. GURSKÁ, M. KHOYLOU, A. ŘEHULKOVÁ, P. KOUŘILOVÁ, J. CHUDÁČEK, M. SZKORUPA, J. KLEIN, J. ŠKARDA, J. SROVNAL a M. HAJDÚCH. Cannabinoid receptor 2 expression in early-stage non-small cell lung cancers identifies patients with good prognosis and longer survival. Translational Lung Cancer Research. 2022, 11 (10), 2040-2050. ISSN: 2218-6751. IF: 4.726. PMID: 36386452 

BARUCIC, D., S. KAUSHIK, J. KYBIC, J. STANKOVÁ, P. DŽUBÁK a M. HAJDÚCH. Characterization of drug effects on cell cultures from phase-contrast microscopy images. Computers in Biology and Medicine. 2022, 151 106171. ISSN: 0010-4825. IF: 6.698. PMID: 36306582

 

GUTIERREZ, J., E. FERNANDEZ-MOREIRA, M. RODRIGUEZ, M. MIJARES, J. DE SANCTIS, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, J. BRUNO-COMENAREZ, L. ROJAS, D. DEFFIUX, L. POUYSEGU, S. QUIDEAU, J. CHARRIS a H. RAMIREZ. Novel 7-Chloro-(4-thioalkylquinoline) Derivatives: Synthesis and Antiproliferative Activity through Inducing Apoptosis and DNA/RNA Damage. Pharmaceuticals. 2022, 15 (10), 1234. ISSN: 1424-8247. IF: 5.215. PMID: 36297346 

YANG, C., L. POSTOVA SLAVETINSKA, M. FLEUTI, B. KLEPETAROVA, M. TICHÝ, S. GURSKÁ, P. PAVLIŠ, P. DŽUBÁK, M. HAJDÚCH a M. HOCEK. Synthesis of Polycyclic Hetero-Fused 7-Deazapurine Heterocycles and Nucleosides through C-H Dibenzothiophenation and Negishi Coupling. Journal of the American Chemical Society. 2022, 144 (42), 19437-19446. ISSN: 0002-7863. IF: 16.383. PMID: 36245092

BARTA, P., R. KAMARAJ, M. KUCHAROVA, Z. NOVÝ, M. PETŘÍK, K. BENDOVÁ, M. HAJDÚCH, P. PÁVEK a F. TREJTNAR. Preparation, In Vitro Affinity, and In Vivo Biodistribution of Receptor-Specific 68Ga-Labeled Peptides Targeting Vascular Endothelial Growth Factor Receptors. Bioconjugate Chemistry. 2022, 33 (10), 1825-1836. ISSN: 1043-1802. IF: 6.069. PMID: 36197842

VRZALOVA, A., P. PECINKOVA, S. GURSKÁ, P. DŽUBÁK, M. SZOTKOWSKI, M. HAJDÚCH, S. MANI a Z. DVORAK. Mixture Effects of Tryptophan Intestinal Microbial Metabolites on Aryl Hydrocarbon Receptor Activity. International Journal of Molecular Sciences. 2022, 23 (18), 10825. ISSN: 1422-0067. IF: 6.208. PMID: 36142735

ŘEHULKA, J., I. SUBTELNA, A. KRYSHCHYSHYN-DYLEVYCH, A. CHERNIIENKO, A. IVANOVA, M. MATVEIEVA, P. POLISHCHUK, S. GURSKÁ, M. HAJDÚCH, O. ZAGRIJTCHUK, P. DŽUBÁK a R. LESYK. Anticancer 5-arylidene-2-(4-hydroxyphenyl)aminothiazol-4(5H)-ones as tubulin inhibitors. Archiv der Pharmazie. 2022, 355 (12), e2200419. ISSN: 0365-6233 . IF: 4.613. PMID: 36109178

BLANCO, Z., E. FERNANDEZ-MOREIRA, M. MIJARES, C. CELIS, G. MARTINEZ, J. DE SANCTIS, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, A. MIJOBA, Y. GARCIA, X. SERRANO, N. HERRERA, J. CORREA-ABRIL, Y. PARRA, J. ANGEL, H. RAMIREZ a J. CHARRIS. Synthesis, Leishmanicidal, Trypanocidal, Antiproliferative Assay and Apoptotic Induction of (2-Phenoxypyridin-3-yl)naphthalene-1(2 H)-one Derivatives. Molecules. 2022, 27 (17), 5626. ISSN: 1420-3049. IF: 4.927. PMID: 36080388

SCHADICH, E., S. NYLEN, S. GURSKÁ, J. KOTULOVÁ, S. ANDRONATI, V. PAVLOVSKY, S. SOBOLEVA, P. POLISHCHUK, M. HAJDÚCH a P. DŽUBÁK. Activity of 1-aryl-4-(naphthalimidoalkyl) piperazine derivatives against Leishmania major and Leishmania mexicana. Parasitology International. 2022, 91 102647. ISSN: 1383-5769. IF: 2.106. PMID: 35985636

Rašková, M.; Lacina, L.; Kejík, Z.; Venhauerová, A.; Skaličková, M.; Kolář, M.; Jakubek, M.; Rosel, D.; Smetana, K., Jr.; Brábek, J. The Role of IL-6 in Cancer Cell Invasiveness and Metastasis—Overview and Therapeutic Opportunities. Cells 2022, 11, 3698. doi: 10.3390/cells11223698

Antonyová, V.; Kejík, Brogyanyi, T.; Kaplánek, R.; Veselá, K.; Abramenko, N.; Ocelka, T.; Masařík, M.; Matkowski, A.; Gburek, J.; Abel, R.; Goede, A.; Preissner, R.; Novotný, P.; Jakubek, M.: Non-Psychotropic Cannabinoids as Inhibitors of TET1 Protein. Bioorg. Chem. 124 (2022) 105793 doi: 10.1016/j.bioorg.2022.105793

Talianová, V.; Kejík, Z.; Kaplánek, R.; Veselá, K.; Abramenko, N.; Lacina, L.; Strnadová, K.; Dvořánková, B.; Martásek, P.; Masařík, M.; Houdová Megová, M.; Bušek, P.; Křížová, J.; Zdražilová, L.; Hansíková, J.; Vlčák, E.; Filimonenko, V.; Šedo, A.; Smetana, K.; Jakubek, M.: New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity. Pharmaceutics 14 (2022) 1712. doi: 10.3390/pharmaceutics14081712

Leischner Fialová, J.; Hönigová, K.; Raudenská, M.; Mikšátková, L.; Zobalová, R.; Navrátil, J.; Šmigová, J.; Moturu, T.R.; Vičar, T.; Balvan, J.; Veselá, K.; Abramenko, N.; Kejík, Z.; Kaplánek, R.; Gumulec, J.; Rösel, D.; Martásek, P.; Brábek, J.; Jakubek, M.; Neužil, J.; Masařík, M.: Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration. Biomed. Pharmacother. 154 (2022) 113582. doi: 10.1016/j.biopha.2022.113582

Antonyová, V.; Tatar, A.; Brogyányi, T.; Kejík, Z.; Kaplánek, R.; Vellieux, F.; Abramenko, N.; Sinica, A.; Hajduch, J.; Novotný, P.; Masters, B.S.; Martásek, P.; Jakubek, M.: Targeting of the Mitochondrial TET1 Protein by Pyrrolo[3,2-b]pyrrole Chelators. Int. J. Mol. Sci. 23 (2022) 10850. doi: 10.3390/ijms231810850

Brogyányi, T.; Kaplánek, R.; Kejík, Z.; Hosnedlová, B.; Antonyová, V.; Abramenko, N.; Veselá, K.; Martásek, P.; Vokurka, M.; Richardson, D.R.; Jakubek, M.: Azulene hydrazide-hydrazones for selective targeting of pancreatic cancer cells. Biomed. Pharmacophor. 155 (2022) 113736. doi: 10.1016/j.biopha.2022.113736

Krečmerová, M. Od 5-azapyrimidinové chemie k thiadiazolům. Chem. Listy 2022, 116, 152-162.

Andrei, G.; Fiten, P.; Krečmerová, M.; Opdenakker, G.; Topalis, D.; Snoeck, R. Poxviruses Bearing DNA Polymerase Mutations Show Complex Patterns of Cross-Resistance. Biomedicines 2022, 10, 580.

Krečmerová, M.; Majer, P.; Rais, R.; Slusher, B. S. Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects. Front. Chem. 2022, 10, 889737. doi: 10.3389/fchem.2022.889737.

Petr Busek, Jonathan S. Duke-Cohan, and Aleksi Sedo: Does DPP-IV Inhibition Offer New Avenues for Therapeutic Intervention in Malignant Disease? Cancers (Basel). 2022 May; 14(9): 2072 doi: 10.3390/cancers14092072

Veronika Talianová, Zdeněk Kejík, Robert Kaplánek, Kateřina Veselá, Nikita Abramenko, Lukáš Lacina, Karolína Strnadová, Barbora Dvořánková, Pavel Martásek, Michal Masařík, Magdalena Houdová Megová,6 Petr Bušek, Jana Křížová, Lucie Zdražilová, Hana Hansíková, Erik Vlčák, Vlada Filimonenko, Aleksi Šedo, Karel Smetana, Jr., and Milan Jakubek: New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity, Pharmaceutics. 2022 Aug; 14(8): 1712 doi: 10.3390/pharmaceutics14081712

Arpas T, Jelinkova H, Hrabovsky S, Orsulova M, Vrzalova Z, Navrkalova V, Brhelova E, Bryjova L, Bulikova A, Ondrouskova E, Sejnohova M, Folber F, Sedová P, Mayer J, Pospisilova S, Jarosova M, Doubek M. Very rare near-haploid acute lymphoblastic leukemia resistant to immunotherapy and CAR-T therapy in 19-year-old male patient. Clin Case Rep. 2022 Mar 3;10(3):e05545. doi: 10.1002/ccr3.5545. PMID: 35280086; PMCID: PMC8894580.

Olbertova H, Plevova K, Pavlova S, Malcikova J, Kotaskova J, Stranska K, Spunarova M, Trbusek M, Navrkalova V, Dvorackova B, Tom N, Pal K, Jarosova M, Brychtova Y, Panovska A, Doubek M, Pospisilova S. Evolution of TP53 abnormalities during CLL disease course is associated with telomere length changes. BMC Cancer. 2022 Feb 3;22(1):137. doi: 10.1186/s12885-022-09221-z. PMID: 35114947; PMCID: PMC8812042.

Zhang Y, Blomquist TM, Kusko R, Stetson D, Zhang Z, Yin L, Sebra R, Gong B, Lococo JS, Mittal VK, Novoradovskaya N, Yeo JY, Dominiak N, Hipp J, Raymond A, Qiu F, Arib H, Smith ML, Brock JE, Farkas DH, Craig DJ, Crawford EL, Li D, Morrison T, Tom N, Xiao W, Yang M, Mason CE, Richmond TA, Jones W, Johann DJ Jr, Shi L, Tong W, Willey JC, Xu J. Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples. Genome Biol. 2022 Jun 29;23(1):141. doi: 10.1186/s13059-022-02709-8. PMID: 35768876; PMCID: PMC9241261.

KOLOUCHOVA, Kristyna, CERNOCHOVA, Zulfiya, GROBORZ, Ondrej, HERYNEK, V., KOUCKY, F., JAKSA, R., BENES, J., SLOUF, Miroslav, HRUBY, Martin. Multiresponsive fluorinated polymers as a theranostic platform using 19F MRI. European Polymer Journal. 2022, 175(15 July), 111381.

SALEK, Petr, DVORAKOVA, Jana, HLADYSH, Sviatoslav, OLESHCHUK, Diana, PAVLOVA, Ewa, KUCKA, Jan, PROKS, Vladimir. Stimuli-responsive polypeptide nanogels for trypsin inhibition. Beilstein Journal of Nanotechnology. 2022, 13(22 Jun), 538-548. doi:10.3762/binano.13 45.

LOBAZ, Volodymyr, KONEFAL, Magdalena, KOTOV, Nikolay, LUKESOVA, Miroslava, HROMADKOVA, Jirina, SLOUF, Miroslav, PANEK, Jiri, HRUBY, Martin, CHMELA, Tomâs, KRUPICKA, Pavel. Low-Melting Phosphate Glass Coatings for Structural Parts Composed of Depleted Uranium. Coatings 2022, 12, 1540. doi: 10.3390/coatin*s12101540 .

SVEC, Pavel, PETROV, 0. V., LANG, 1., STEPNICKA, P., GROBORZ, Ondfej, DUNLOP, David, BLAHUT, 1., KOLOUCHOVA, Kristyna, LOUKOTOVA, Lenka, SEDLACEK, 0., HEIZER, T., TOSNER, Z., SLOUF, Miroslav,

BENES, Hynek, HOOGENBOOM, R., HRUBY, Martin. Fluorinated ferrocene moieties as a platform for redox-responsive polymer 19F MRI theranostics. Macromolecules. 2022, 55(2), 658-671. doi10.1021/acs.macromoI.1c01723.

LEBEDINSKIY, Konstantin, LOBAZ, Volodymyr, JINDRICH, Jindrich. Preparation of §-cycIodextrin-based dimers with selectively methylated rims and their use for solubilization of tetracene. Beilstein Journal of Organic Chemistry 2022, 18, 1596—1606. doi: 10.3762/bjoc.18.170 .

Elter J. K., Hruby, Martin. Solid-phase synthesis as strategy for the generation of multifunctional, branched polymers, EPF 2022 Congress, Praha, 26.6.-1.7.2022, Book of Abstract 27.6.2022, 12:30 SYNT-C05, 397_Abstract.pdf

Vrbata D, Filipová M, Tavares MR, Červený J, Vlachová M, Šírová M, Pelantová H, Petrásková L, Bumba L, Konefał R, Etrych T, Křen V, Chytil P, Bojarová P. Glycopolymers Decorated with 3-O-Substituted Thiodigalactosides as Potent Multivalent Inhibitors of Galectin-3. J Med Chem. 2022 Mar 10;65(5):3866-3878. doi: 10.1021/acs.jmedchem.1c01625.

Hovorková M, Červený J, Bumba L, Pelantová H, Cvačka J, Křen V, Renaudet O, Goyard D, Bojarová P. Advanced high-affinity glycoconjugate ligands of galectins. Bioorg Chem. 2022 Nov 19;131:106279. doi: 10.1016/j.bioorg.2022.106279.

Golshani M, Rahman WU, Osickova A, Holubova J, Lora J, Balashova N, Sebo P, Osicka R. Filamentous Hemagglutinin of Bordetella pertussis Does Not Interact with the β2 Integrin CD11b/CD18. Int J Mol Sci. 2022 Oct 20;23(20):12598. doi: 10.3390/ijms232012598.

Klimova N, Holubova J, Streparola G, Tomala J, Brazdilova L, Stanek O, Bumba L, Sebo P. Pertussis toxin suppresses dendritic cell-mediated delivery of B. pertussis into lung-draining lymph nodes. PLoS Pathog. 2022 Jun 6;18(6):e1010577. doi: 10.1371/journal.ppat.1010577. eCollection 2022 Jun.

Holubova J, Stanek O, Juhasz A, Hamidou Soumana I, Makovicky P, Sebo P. The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model. PLoS Pathog. 2022 Apr 8;18(4):e1010402. doi: 10.1371/journal.ppat.1010402. eCollection 2022 Apr.

Ambroz, A.; Rossner, P., Jr.; Rossnerova, A.; Honkova, K.; Milcova, A.; Pastorkova, A.; Klema, J.; Pulkrabova, J.; Parizek, O.; Vondraskova, V.; et al. Oxidative Stress and Antioxidant Response in Populations of the Czech Republic Exposed to Various Levels of Environmental Pollutants. Int. J. Environ. Res. Public Health 2022, 19, 3609.

Michal Sima, Tereza Cervena, Fatima Elzeinova, Antonin Ambroz, Vit Beranek, Michal Vojtisek-Lom, Jiri Klema, Miroslav Ciganek, Pavel Rossner. The impact of extractable organic matter from gasoline and alternative fuel emissions on bronchial cell models (BEAS-2B, MucilAir™). Toxicology in Vitro. Volume 80, 2022, 105316.

Martino F, Mysore Varadajan N, Perestrelo AR, Hejret V, Durikova H, Vukic D, Horvath V, Cavalieri F, Caruso F, Albihlal WS, Gerber AP, O’Connell MA, Vanacova S, Pagliari S, Forte G. The mechanical regulation of RNA binding protein hnRNPC in the failing heart. Sci Transl Med (2022) doi: 10.1126/scitranslmed.abo5715.

Zancla A, Mozetic P, Orsini M, Forte G*, Rainer A*. A primer to traction force microscopy. J Biol Chem 2022. DOI: 10.1016/j.jbc.2022.101867. *equal contribution.

Carna M, Onyango IG, Katina S, Holub D, Nezvedova M, Jha D, Nedelska Z, Lacovich V, Vande Vyvere T, Houbrechts R, Garcia-Mansfield K, Sharma R, David-Dirgo V, Vyhnalek M, Texlova K, Šitina M, Chaves H, Bakkar H, Pertierra L, Coufalikova K, Vinkler M, Markova H, Laczo J, Sheardova K, Frič J, Forte G, Belaškova S, Damborsky J, Hort J, Bowser R, Sevlever G, Rissman RA, Smith RA, Hajduch M, Pirrotte P, Spacil Z, Limbäck-Stokin C, Stokin GB. Pathogenesis of alzheimer's disease: involvement of the choroid plexus. Alzheimer's & Dementia (2022). In press.

Pesce M, Duda G, Forte G, Girao F, Raya A, Roca-Cusachs P, Sluijter J, Tschöpe C, Van Linthout S. Cardiac fibroblasts and mechanosensation: inseparably tied in heart development, health and disease. Nat Rev Cardiol (2022). doi: 10.1038/s41569-022-00799-2.

Wojnilowicz M, Laznickova P, Tidu F, Bendickova K, Forte G, Plebanski M, Caruso F, Cavalieri F, Fric J. Interactions of glycogen-siRNA constructs with peripheral blood mononuclear system. Biomater Adv (2022). In press.

Fornetti E, Testa S, De Paolis F, Fuoco C, Bernardini S, Pozo Devoto V, Stokin GB, Giannitelli SM, Rainer A, Bigot A, Zoccali M, Baldi J, Sandonà D, Rizzi R, Bearzi C, Forte G, Cannata S, Gargioli C. Dystrophic muscle affect motoneuron axon outgrowth and NMJ assembly. Adv Mater Technol (2022). doi: 10.1002/admt.202101216.