Publications

US 63/063,734.  Slusher, B.; Rais, R.; D´Alessio, F.; Majer, P.; Krečmerová, M.; Yegnasubramanian, V. Decitabine   Analogs for Immunological and Oncological Therapy. Application Type: Provisional. Filed 10-Aug-2020.

Prodrugs of 6-Mercaptopurine. Date of filing: 25-Aug-2020, US Patent App. No. 63/069,876; JHU Ref.: C16300_P16300-01.

A MEDICINAL PRODUCT FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY AND DEGENERATIVE DISEASES. Inventors: Cejkova J., C. Cejka, S. Kubinova, I. Vackova.
Priority application: CZ PV 2017-84
Published: CZ 307851 (15.05.2019)
Ownership: Ustav experimentálni mediciny AV CR.

PHOTOACTIVATABLE NANOPARTICLES FOR PHOTODYNAMIC APPLICATIONS, METHOD OF THEIR PREPARATION, PHARMACEUTICAL COMPOSITION CONTAINING THESE PARTICLES AND THEIR USE. Inventors: Hruby M., I. Brezaniova, V. Kral.
Priority application: CZ PV 2016-119
Published: CZ 307681 (03.01.2019)
Ownership: : Ustav makromolekularni chemie AV CR, Vysoka skola chemicko-technologicka v Praze.

A METHOD OF INCREASING THE SIGNAL OF ANTIBODIES RECOGNIZING 5-BROMO-2'-DEOXYURIDINE AND/OR 5-CHLORO-2'-DEOXYURIDINE AND/OR 5-IODO-2'-DEOXYURIDINE AT SITES OF INCORPORATION OF THESE NUCLEOSIDES INTO DNA FOR DNASE I ACTIVITY. Inventors: Koberna K., A. Ligasova.
Priority application: CZ PV 2016-87
Published: CZ 307807 (10.04.2019)
Ownership: Univerzita Palackeho v Olomouci.

SUBSTITUTED THIENOPYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE. Inventors: Hocek M., M. Tichy, M. Hajduch, P. Dzubak
Priority application: PCT/CZ2016/050021
Published: US 10,414,788 (17.09.2019)
Ownership: Univerzita Palackeho v Olomouci.

SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE. Hocek M., A. Tokarenko, S. Smolen, M. Hajduch, P. Dzubak.
Priority application: CZ PV 2016-465
Published: CZ 307334 (02.05.2018), EP 3494122 (18.09.2019)
Ownership: Ustav organicke chemie a biochemie AV CR, Univerzita Palackeho v Olomouci.

A METHOD OF DETERMINING THE AMOUNT OF DNA IN SAMPLES, A SET FOR DETERMINING THE AMOUNT OF DNA IN SAMPLES, AND USE THEREOF. Inventors: Koberna K., A. Ligasova.
Priority application: CZ PV 2017-233
Published: CZ 307415 (01.08.2018), EP 3395956 (13.11.2019)
Ownership: Univerzita Palackeho v Olomouci.

PYRIDINOPYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE. Inventors: Veselovska L., M. Hocek, M. Hajduch, P. Dzubak.
Priority application: CZ PV 2018-121
Published: CZ 308104 (27.11.2019)
Ownership: Ustav organicke chemie a biochemie AV CR, Univerzita Palackeho v Olomouci.

METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMENS FOR OVERCOMING RESISTANCE. Inventors: Khushboo A., F. Ivo, P. Dzubak, M. Hajduch
Priority application: EP 14161897.5
Published: JP 6463372 (11.01.2019)
Ownership: Univerzita Palackeho v Olomouci.

IODINATED ANALOGS OF CHOLINE, METHODS OF PREPARATION THEREOF, AND USE THEREOF AS MEDICAMENTS. Inventors: Švec, P., M. Hrubý, J. Kučka, O. Sedláček, M. Petřík, Z. Nový, M. Hajdúch.
Priority application: CZ PV 2016-117
Published: WO 2017/148455 (08.09.2017), EP 3423441 (09.01.2019)
Ownership: Ustav makromolekularni chemie AV CR, Univerzita Palackeho v Olomouci.

METHOD OF PREPARATION OF A SOLUBLE FORMULATION OF WATER-INSOLUBLE PENTACYCLIC AND TETRACYCLIC TERPENOIDS, A SOLUBLE FORMULATION OF A PENTACYCLIC OR TETRACYCLIC TERPENOID AND A PHARMACEUTICAL COMPOSITION CONTAINING THIS SOLUBLE FORMULATION. Inventors: Šarek, J., M. Hajdúch, M. Svoboda, K. Nováková, P. Spáčilová, T. Kubelka, D. Biedermann.
Priority application: CZ PV 2006-606
Published: WO 2008/037226 (03.04.2008), EP 2068882 (23.08.2017)
Ownership: Univerzita Karlova v Praze, Univerzita Palackeho v Olomouci, I.Q.A.

SUBSTITUTED 7-DEZAPURIN RIBONUCLEOSIDES. Inventors: Hocek, M., P. Nauš , O. Caletková, P. Džubák, M. Hajdúch.
Priority application: CZ PV 2013-845
Published: US 9,586,986 (07.03.2017), CZ 305466 (07.09.2015)
Ownership: Ustav organické chemie a biochemie AV CR, Univerzita Palackeho v Olomouci, 

METHOD OF DETERMINATION OF CANCER CELL DRUG SENSITIVITY TOWARDS AURORA KINASE INHIBITORS AND OVERCOMIMG THEIR RESISTANCE. Inventors: Kollaredy, M., M. Hajdúch, P. Džubák, J. Srovnalf, Hrabáková, Kovářová Hana.
Priority application: EP 11192330.6
Published: JP 6144696 (19.05.2017)
Ownership: Univerzita Palackeho v Olomouci, Ustav zivocisne fyziologie a genetiky AV CR

A METHOD OF STABILIZING ANTIBODIES RECOGNIZING 5-BROMO-2'-DEOXYURIDINE AND/OR 5-CHLORO-2'-DEOXYURIDINE AND/OR 5-IODO-2'-DEOXYURIDINE AT SITES OF INCORPORATION OF THESE NUCLEOSIDES INTO THE DNA AFTER TREATMENT WITH MONOVALENT COPPER AND/OR EXONUCLEASE III. Inventors: Koberna Karel, Ligasová Anna.
Priority application: CZ PV 2015-183
Published: CZ 307 016 (04.10.2017)
Ownership: Univerzita Palackeho v Olomouci

METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMENS FOR OVERCOMING RESISTANCE. Inventors: Agrawal K., I. Frydrych, P. Džubák, M. Hajdúch.
Priority application: EP 14161897.5
Published: EP 2924125 (17.06.2017) 
Ownership: Univerzita Palackeho v Olomouci

BENZOISOTHIAZOLE-1, 1-DIOXIDE-3-HYDRAZONES AND THEIR USE IN ANTICANCER THERAPY. Inventors: Kaplánek R., T. Bříza, M. Havlík, J. Rak, Z. Kejík, P. Džubák, M. Hajdúch, P. Konečný, J. Štěpánková, J. Králová, V. Král.
Priority application: PV 2014-322
Published: CZ 306554 (25.01. 2017)
Ownership: Vysoka skola chemicko-technologicka v Praze, Univerzita Palackeho v Olomouci, Ustav molekularni genetiky AV CR

DEVICE FOR STORAGE, TRANSPORT AND APPLICATION OF STEM CELLS. Inventors: Petrenko, Y., E. Syková, J. Čejková, I. Vacková, T. Groh.
Priority application: CZ PV 2016-284
Published: CZ 306800 (12.07.2017)
Ownership: Ustav experimentalni mediciny AV CR

PHOTOACTIVATABLE NANOPARTICLES FOR PHOTODYNAMIC APPLICATIONS, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USE THEREOF. Hruby, M., I. Brezaniova, V. Kral. 
Priority application: CZ PV 2016-119
Published: WO 2017/148454 (08.09.2017), CZ 307681 (03.01.2019)
Ownership: Ustav makromolekularni chemie AV CR, Vysoka skola chemicko-technologicka v Praze

ASYMMETRIC TROGER BASES WITH HYDRAZONE GROUP AND THEIR USE IN THE TREATMENT OF ONCOLOGIC DISEASES. Inventors: Inventors: Rak, J., R. Kaplánek, T. Štulcová, P. Drašar, M. Havlík, T. Bříza, P. Džubák, M. Hajdúch, P. Konečný, J. Štěpánková, J. Králová, V. Král.
Priority application: CZ PV 2014-317
Published: CZ 305683 (23.12.2015)
Ownership: Vysoka skola chemicko-technologicka v Praze, Univerzita Palackeho v Olomouci, Ustav molekularni genetiky AV CR

DIOXOCYCLOBUTENYL HYDRAZONES AND THEIR ANTICANCER ACTIVITY. Inventors: Havlík, M., R. Kaplánek, B. Dolenský, J. Rak, T. Bříza, P. Džubák, M. Hajdúch, P. Konečný, J. Štěpánková, J. Králová, V. Král.
Priority application: CZ PV 2014-321
Published: CZ 305626 (02.12.2015)
Ownership: Vysoka skola chemicko-technologicka v Praze, Univerzita Palackeho v Olomouci, Ustav molekularni genetiky AV CR

CAFFEINE-8-HYDRAZONES AS NOVEL CYTOSTATICS FOR THE TREATMENT OF ONCOLOGIC DISEASES. Inventors: Rak, J., R. Kaplánek, T. Štulcová, P. Drašar, M. Havlík, T. Bříza, P. Džubák, M Hajdúch, P. Konečný, J. Štěpánková, J. Králová, V. Král.
Priority application: CZ PV 2014-307
Published: CZ 305625 (02.12.2015)
Ownership: Vysoka skola chemicko-technologicka v Praze, Univerzita Palackeho v Olomouci, Ustav molekularni genetiky AV CR

CHOLYL HYDRAZONES AND THEIR USE IN THE TREATMENT OF TUMOR AND LEUKEMIA DISEASES. Inventors: Rak, J., R. Kaplánek, T. Štulcová, P. Drašar, M. Havlík, T. Bříza, P. Džubák, M Hajdúch, P. Konečný, J. Štěpánková, J. Králová, V. Král.
Priority application: CZ PV 2014-305
Published: CZ 305607 (25.11.2015)
Ownership: Vysoka skola chemicko-technologicka v Praze, Univerzita Palackeho v Olomouci, Ustav molekularni genetiky AV CR

METHOD OF PREPARATION OF A SOLUBLE FORMULATION OF WATER-INSOLUBLE PENTACYCLIC AND
TETRACYCLIC TERPENOIDS, A SOLUBLE FORMULATION OF A PENTACYCLIC OR TETRACYCLIC TERPENOID
AND A PHARMACEUTICAL COMPOSITION CONTAINING THIS SOLUBLE FORMULATION. Inventors: Šarek,
J., M. Hajdúch, M. Svoboda, K. Nováková, P. Spáčilová, T. Kubelka, D. Biedermann.
Priority application: CZ PV 2006-606
Published: CA 2 762 911 (05.11.2013)
Ownership: Univerzita Karlova v Praze, Univerzita Palackeho v Olomouci, I.Q.A.

LIGHT SOURCE WITH LUMINOUS FIELD HOMOGENEITY, ESPECIALLY FOR INDUCING AND MONITORING PHOTODYNAMIC PHENOMENON IN VITRO. Inventors: Bajgar, R., H. Kolářová.
Priority application: CZ PV 2009-863
Published: SK 288148 (16.09.2013)
Ownership: Univerzita Palackeho v Olomouci

DERIVATIVES OF 2-PHENYL-3-HYDROXYQUINOLINE-4(1H)-ONE AND METHODS OF THEIR PREPARATION AND UTILIZATION. Inventors: Krejčí, P., P. Hradil, J. Hlaváč, M. Hajdúch.
Priority application: CZ PV 2006-546
Published: EP 2064200 (04.09.2013)
Ownership: Univerzita Palackeho v Olomouci, Masarykuv onkologicky ustav

METHOD FOR DETERMINING THE SENSITIVITY OF PATIENTS SUFFERING FROM A CANCER DISEASE TO BIOLOGICAL THERAPY. Inventors: Hajdúch, M., M. Dziechciarková, L. Radova, M. Svoboda..
Priority application: CZ PV 2008-40
Published: JP 5295268 (21.06.2013), US 8465936 (18.06.2013)
Ownership: Univerzita Palackeho v Olomouci, Masarykuv onkologicky ustav

METHOD OF PREPARATION AND ISOLATION OF BETULIN DIACETATE FROM BIRCH BARK FROM PAPER MILLS AND ITS OPTIONAL PROCESSING TO BETULIN. Inventors: Šarek, J., M. Svoboda, M. Hajdúch.
Priority application: CZ PV 2007-36
Published: CA 2673226 (08.01.2013)
Ownership: Univerzita Karlova v Praze, Univerzita Palackeho v Olomouci; I.Q.A.

DEVICE FOR ULTRASONIC IRRADIATION OF SAMPLES. Inventors: Doležal, L., H. Kolářová, J. Hradil.
Priority application: CZ PV 2008-730
Published: CZ 303782 (20.03.2013)
Ownership: Univerzita Palackeho v Olomouci