Trhlíková Zdeňka

Skupiny: BAKALÁŘSKÝ STUDENT

Preparation of heterocyclic triterpenes

The main aim is to prepare a small set of new heterocyclic triterpenoid derivatives using condensation reactions of triterpenoid precursors with ethylene diamine, urea derivatives, hydrazine and other small molecules. Our previous research of triterpenoid heterocycles resulted in several compounds with high in vitro cytotoxic activity and this work should further explore this topic. New derivatives prepared within this work will be tested for their in vivo cytotoxic activity and the best candidates will be selected for more biological examinations.

Vedoucí: Urban Milan Ph.D.

Stav: Graduated od 2013 do 2017.

HODOŇ, J., I. FRYDRYCH, Z. TRHLÍKOVÁ, J. POKORNÝ, L. BORKOVÁ, S. BENICKÁ, M. VLK, B. LIŠKOVÁ, A. KUBÍČKOVÁ, M. MEDVEDÍKOVÁ, M. PISÁR, J. ŠAREK, V. DAS, A. LIGASOVÁ, K. KOBERNA, P. DŽUBÁK, M. HAJDÚCH, M. URBAN

Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs. European Journal of Medicinal Chemistry. 2022, 243, 114777, ISSN: 0223-5234, PMID: 36174412, PDF.

HOLUBOVA, M., V. LOBAZ, L. LOUKOTOVA, M. RABYK, J. HROMADKOVA, Z. TRHLÍKOVÁ, Z. PECHROVA, O. GROBORZ, P. STEPANEK, M. HRUBY

Chemically modified glycogens: how they influence formation of amyloid fibrils?. Soft Matter. 2021, 17(6), 1614-1627, ISSN: 1744-683X, PMID: 33355593,

HOLUBOVA, M., V. LOBAZ, L. LOUKOTOVA, M. RABYK, J. HROMADKOVA, Z. TRHLÍKOVÁ, Z. PECHROVA, O. GROBORZ, P. STEPANEK, M. HRUBY

Does polysaccharide glycogen behave as a promoter of amyloid fibril formation at physiologically relevant concentrations? . Soft Matter. 2020, 17(6), 1628-1641, ISSN: 1744-683X, PMID: 33355589,

Trhlíková Zdeňka

Bakalářské studium

Journals