Urban Milan Ph.D.

Akademický titul: Associate Professor

Telefon: +420 585 632 197

Skupiny: ÚMTM, LEM, PERSONÁL, VEDOUCÍ

I am a scientist in the field of medicinal chemistry with current focus on natural products with various biological activities. Since 2012 I am a leader of an independent research group that currently has 2 postdocs, 4 PhD and 8 undergraduate students. Our research consists of organic synthesis, evaluation of activities and mechanism of action. I have been a PI of several grant projects from Czech Science Agency and from the Ministry of Health of the Czech Republic. Currently I serve on an evaluation panel of Czech Science Agency (P207). Earlier in my career, I was also involved in nucleic acid research, enzymology and biochemistry in general. In addition, I teach classes on bioorganic chemistry, chemical biology, and chemistry of nucleic acids. Published more than 40 papers, 3 book chapters, 4 patents, >1500 SCI citations, H-index 21.

ORCID: http://orcid.org/0000-0002-8249-028X

Researcher ID: C-9611-2010

BACHOŘÍK, J., I. FRYDRYCH, S. GURSKÁ, S. DOSTAL, J. POKORNÝ, M. HAJDÚCH, M. URBAN

New Synthetic Approach to C‑30 Ethers, Esters, and Amines of Betulin Using the Mitsunobu Reaction and Biological Evaluation of the Products. ACS Omega. 2026, 11(16), 24564-24579, ISSN: 2470-1343, PMID: 42077890, PDF.

KAZAKOVA, A., I. FRYDRYCH, N. JAKUBCOVÁ, J. POKORNÝ, B. LIŠKOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, M. URBAN

Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells – Synthesis, potency, and mitochondrial mechanism of action. European Journal of Medicinal Chemistry. 2024, 269, 116336, ISSN: 0223-5234, PMID: 38520761, PDF.

BORKOVÁ, L., I. FRYDRYCH, B. VRÁNOVÁ, N. JAKUBCOVÁ, B. LIŠKOVÁ, P. DŽUBÁK, P. PAVLIŠ, M. HAJDÚCH, M. URBAN

Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes. European Journal of Medicinal Chemistry. 2022, 244, 114850, ISSN: 0223-5234, PMID: 36283179,

DŽUBÁK, P., M. URBAN, M. HAJDÚCH

Vývoj nových léčiv, 1. vyd, Praha, Galén, 2015, 11, 469-472, ISBN: 978-80-7492-121-6,

URBAN, M., M. KVASNICA, N. DICKINSON, J. ŠAREK

Biologically Active Triterpenoids Usable As Prodrugs, 1. vyd, New York, USA, Nova Science Publishers, 2015, 2, 25-50, Dedication: CZ.1.05/2.1.00/01.0030, ISBN: 978-1-63463-656-8,

ŠAREK, J., M. KVASNICA, M. VLK, M. URBAN, P. DŽUBÁK, M. HAJDÚCH

The Potential of Triterpenoids in the Treatment of Melanoma, 1.vyd, Rijeka, InTech, 2011, 7, 125-158, Dedication: 305/09/1216, ISBN: 978-953-307-293-7,

C-28 BIOTINYLATED HETEROCYCLIC TRITERPENES OF A LUPANINE TYPE AND THEIR USE (Urban)

Patent: CZ 307 165; Granted: 3.1.2018; Ownership: Palacky University, Olomouc; Inventors: Urban Milan, Soural Miroslav, Šarek Jan

Status: Terminated

C-3 BIOTINYLATED TRITERPENES OF A LUPANINE TYPE AND THEIR USE (Urban)

Patent: CZ 307227; Granted: 28.2.2018; Ownership: Palacky University, Olomouc; Inventors: Urban Milan, Soural Miroslav, Šarek Jan

Status: Terminated

TERPENOID DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN NEUROPROTECTION (Urban)

Published Application: PV 2020-651 (15.6.2022). Inventors: URBAN Milan, GONZALEZ Gabriel, HODOŇ Jiří, STRNAD Miroslav. Ownership: Palacký University Olomouc.
Published Application: PCT/CZ2021/050146 under WO 2022/117133 (9.6.2022). Inventors: URBAN Milan, GONZALEZ Gabriel, HODOŇ Jiří, STRNAD Miroslav. Ownership: Palacký University Olomouc.

Status: Patent pending; Available

Bachořík Jan

Preparation of semisynthetic triterpenes

Stav: Probíhající od 2019.

2 Molecular and Translational Medicine

Projekt:	Modifications of biologically active molecules leading to improvement of their pharmacological properties
Vedoucí:	Urban Milan Ph.D., Ranc Václav Ph.D., Polishchuk Pavlo Ph.D., M.Sc.
K dispozici:	3
Určeno pro:	Doctoral training

Projekt:	Research and development of agents for cancer, neurodegenerative and infectious diseases
Vedoucí:	De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
K dispozici:	5
Určeno pro:	Doctoral training

Urban Milan Ph.D.

O mně

Journals

Books & book chapters

Intellectual property

Doctoral mentorship

Bachořík Jan

Orság Šimon

Jurčeka Ondřej

Master mentorship

Maršálková Natálie

Horka Vladimír

Pisár Martin

Bachelor mentorship

Zamazal Viktor

Jarošová Amálie

Oriešková Eliška

Volná místa