Srovnal Josef M.D., Ph.D.
About me
Scientist and medical professional mainly involved in molecular and translational medicine (disease area paediatric, oncology and medical genetics). Experienced in project management and certification processes, involved as investigator in more than 20 national and international projects, co-founder of spin-off company focused on manufacturing of molecular diagnostics.
Published more than >65 papers, >7books/chapters, >2 patents, >290 oral/poster presentations, >1000 SCI citations, H-index 12
Specialties:
Molecular and translational medicine
Pediatrics, Oncology and Medical Genetics
Circulating tumor cells detection
Molecular profilling of tumors
Prognostic, predictive and diagnostic biomarkers
Responsibility for transcriptomic sequencing, circulating tumor cells detection, PCR based methods, gene expression profiling, SNP and CNV arrays. Biostatistical analyses. Biomedical project coordinator. Quality manager (ISO 15189). Teaching and examination of students, tutor for Bc., MSc. and PhD. students.
Journals
Books & book chapters
Intellectual property
- Published Application PCT/EP2013/057111 under WO 2013/152989 (17.10.2013)
Status: Terminated
- Published Application PCT/CZ2012/000123 under WO 2013/083098 (13.6.2013)
- Patent: EP 2788504; Granted: 21.7.2016; Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics CAS; Inventors: Kollaredy Madhusudhan, Hajdúch Marián, Džubák Petr, Srovnal Josef, Hrabáková, Kovářová Hana
- Patent: JP 6144696; Granted: 19.5.2017; Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics CAS; Inventors: Kollaredy Madhusudhan, Hajdúch Marián, Džubák Petr, Srovnal Josef, Hrabáková, Kovářová Hana
- Patent: CA 2.855.921; Granted: 5.3.2019; Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics CAS; Inventors: Kollaredy Madhusudhan, Hajdúch Marián, Džubák Petr, Srovnal Josef, Hrabáková, Kovářová Hana
- Published Application US 2014/0336073 (13.11.2014)
Status: Terminated
Doctoral mentorship
Vidlařová Monika M.Sc.
Detection and clinical importance of circulating tumor cells in solid tumours
Slavík Hanuš M.Sc.
Minimal residual disease in solid cancers
Řehulková Alona M.D.
Prognostic and predictive factors in solid tumors
Master mentorship
Kvapil Marek
Liquid colorectal cancer biopsy
Ondrouch Jakub B.Sc.
miRNA expression profiling in oesophageal disease
Bačová Zuzana M.Sc.
Gene expression profiling in hematological malignancies
Bachelor mentorship
Tinková Eva
MirRNA expression profiling in Barrett’s oesophagus
Hošková Kateřina
Chromosomal aberations analysis in children with autistic spectrum disorders
Horáková Kateřina
The RNA stability and degradation in the blood tubes
Open positions
2 Medical biology
| Project: | Diagnostics and therapy of rare diseases |
|---|---|
| Supervisors: | Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Summary: | 2 places in full-time study |
| Project: | New prognostic and predictive factors in solid tumors |
|---|---|
| Supervisors: | Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D. |
| Available: | 3 |
| Intended for: | Doctoral training |
| Summary: | 3 places in full-time or combined form of study |
1 Biomarkers: Identification and validation
| Project: | New prognostic and predictive factors in solid tumors |
|---|---|
| Supervisors: | Srovnal Josef M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Summary: | Cancer is the second leading cause of death in the western countries. Early diagnosis and targeted therapy improve the therapeutic outcome. With the emergence of new biotechnologies, diagnosis can be made early and precisely, and the knowledge of tumor molecular genetics can identify the most appropriate therapy for a particular patient. The sensitivity of modern molecular methods makes it possible to characterize the tumor properties from sites remote from the primary tumor using patient's blood. The subject of the offered study program is the identification of new prognostic and predictive biomarkers of cancer using liquid biopsies. This is particularly the analysis of circulating tumor cells (CTCs), circulating free tumor DNA (ctDNA) and circulating miRNAs. The aim of the project is to further implement a liquid biopsy concept into the diagnosis and therapy monitoring of solid tumors, especially colorectal, breast, lung and CNS tumors. These include therapy response and resistance monitoring, identifying new therapeutic targets and estimating disease prognosis. The project will provide training in widely-used, transferable techniques, including circulation tumor cells capture system, digital droplet PCR, reverse-transcription qPCR, RNA-seq, single cell analyses, xenografts models and other multi-omics methods. We are looking for candidates with a background in Molecular Biology, Medicine, Cell Biology or a related area, who are enthusiastic about investigating novel approaches in cancer diagnostic that have significant potential for public health. |
3 Molecular and Translational Medicine
| Project: | Diagnosis and treatment of rare diseases |
|---|---|
| Supervisors: | Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Project: | New prognostic and predictive factors in solid tumors |
|---|---|
| Supervisors: | Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D., Koudeláková Vladimíra Ph.D. |
| Available: | 3 |
| Intended for: | Doctoral training |
| Project: | Liquid biopsies in experimental and clinical oncology |
|---|---|
| Supervisors: | Srovnal Josef M.D., Ph.D., Koudeláková Vladimíra Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |