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Academic title: MSc.
Phone: 585 632 144
Groups: BACHELOR STUDENT, DOCTORAL STUDENT, IMTM, LEM, MASTER STUDENT, STAFF

Doctoral training

Cytotoxic drugs molecular target identification by methods of cell biology and proteomics

Molecular target identification of biologically active molecules is a key factor facilitating rational design and preclinical development of potential drugs. Methods of cellular biology, chemical proteomics and mass spectrometry are developed and used for its purposes.

Specialization: Pediatrics
Status: Ongoing from 2016.

Master training

Proteomic profile of CCRF-CEM cell line treated by 5-fluorouracil

Status: Graduated from 2014 to 2016.

Bachelor training

Determination of the efficacy of 5-fluorouracil on line CCRF-CEM T

Status: Graduated from 2014 to 2014.

About me

I am a research assistant and Ph.D. candidate at the Institute of Molecular and Translational Medicine in Olomouc, Czech Republic. Since 2016 I have been participating in the research program Chemical Biology and Experimental Therapeutics, mainly focusing on new methods for molecular target identification, such as microscopy and proteomics methods. I joined the multi-omics group in 2020 and currently working on the proteomics part of the EATRIS-Plus project.

Journals

Terpenes and Terpenoids Conjugated with BODIPYs: An Overview of Biological and Chemical Properties. Journal of Natural products. 2024, 87(4), 1306-1319, ISSN: 0163-3864, PMID: 38482846,  PDF.
BARUCIC, D., S. KAUSHIK, J. KYBIC, J. STANKOVÁ, P. DŽUBÁK, M. HAJDÚCH
Characterization of drug effects on cell cultures from phase-contrast microscopy images. Computers in Biology and Medicine. 2022, 151, 106171, ISSN: 0010-4825, PMID: 36306582,
PORUBSKÝ, M., S. GURSKÁ, J. STANKOVÁ, M. HAJDÚCH, P. DŽUBÁK, J. HLAVÁČ
Amino-BODIPY as the ratiometric fluorescent sensor for monitoring drug release or "power supply" selector for molecular electronics. RSC Advances. 2019, 9(43), 25075-25083, ISSN: 2046-2069, PMID: 35528670,

Books & book chapters

Reporters for subcellular localization and image analysis , 1.vyd., Olomouc, Palacky University, 2021, 19, 141-146, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Master mentorship

Křesťanová Eliška

Development of DIA method useful for plasma proteomic profiling of large sample cohort

Status: Ongoing from 2022.

Bachelor mentorship

Burgetová Ječmeňová Kateřina

Spectroscopic characteristics used drugs and their use in the identification of molecular targets

Status: Graduated from 2016 to 2018.

Hladíková Eliška

Reporter lentiviral systems for subcellular localization

Status: Graduated from 2019 to 2020.