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Phone: +421911438047
Groups: DOCTORAL STUDENT, IMTM, LIG, STAFF

Doctoral training

DNA replication and cancer

Specialization: Medical genetics
Status: Ongoing from 2020.

About me

PhD student in the 4th year of study, and a member of the DNA Replication Dynamics group. Specializing in the DNA replication machinery in cancer cell lines, with a focus on replication stress and replication stress responses caused by PARP inhibitors (PARPi). We investigate these processes using various approaches, including advanced laser microscopy methods, cell cultures, and immunoblotting.

Journals

The need for speed: drivers and consequences of accelerated replication forks. Communications Biology. 2025, 8(1), 1538, ISSN: 2399-3642, PMID: 41198817,
BUCHTOVÁ, T., D. LUKÁČ, Z. ŠKROTT, K. CHROMÁ, J. BÁRTEK, M. MISTRÍK
Drug-Drug Interactions of Cannabidiol with Standard-of-Care Chemotherapeutics. International Journal of Molecular Sciences. 2023, 24(3), 2885, ISSN: 1422-0067, PMID: 36769206,  PDF.
Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments. Life Science Alliance. 2022, 5(12), e202201560, ISSN: 2575-1077, PMID: 36260751,

Bachelor mentorship

Kočářová Natálie

Effect of olaparib on DNA damage signalling

Status: Ongoing from 2023.