Škrott Zdeněk Ph.D.
About me
Junior researcher interested in protein homeostasis and degradation pathways in cancer and other diseases. Interested in microscopic techniques and live-cell imaging.
Author of 14 original scientific publications with over 600 SCI citations.
Journals
A Phase 1/2 Study of Disulfiram and Copper With Concurrent Radiation Therapy and Temozolomide for Patients With Newly Diagnosed Glioblastoma. International Journal of Radiation Oncology, Biology, Physics. 2024, 120(3), 738-749, ISSN: 0360-3016, PMID: 38768767,
Identification of novel dithiocarbamate-copper complexes targeting p97/NPL4 pathway in cancer cells. European Journal of Medicinal Chemistry. 2023, 261, 115790, ISSN: 0223-5234 , PMID: 37690264,
Books & book chapters
Methods for detection and induction of proteotoxic stress response in mammalian cells , 1.vyd., Olomouc, Palacky University, 2021, 23, 169-176, Dedication: LO1304, ISBN: 978-80-244-6049-9,
Intellectual property
BIOAVAILABLE DITHIOCARBAMATE-METAL COMPLEX NANOPARTICLES, METHOD OF PREPARATION AND USE THEREOF "DISULFIRAM I" (Škrott)
- Patent: EP 3459526. Granted: 24.2.2021. Ownership: Palacky University, Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
- Published Application PCT/EP2018/076098 under WO 2019/063601 (4.4.2019)
- Patent: AU 2018340510. Granted: 5.8.2021. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
- Patent: CA 3,076,855. Granted: 26.4.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
- Patent: KR 10-2456683. Granted: 14.10.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
- Patent: JP 2020-537873. Granted: 29.9.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
- Patent: MX 396,552. Granted: 17.10.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
Status: Available
CELL CULTURE DEVICE AND METHOD FOR THERMAL MICRO-IRRADIATION OF CELLS "PLASMONS" (Mistrík)
- Published Application: EP 20198904.3 under EP 20198904 (7.4.2022). Ownership: Palacky University, Olomouc. Inventors: Mistrík Martin, Škrott Zdeněk, Bártek Jiří, Panáček Aleš, Kvítek Libor, Hochvaldová Lucie.
Status: Terminated
LIQUID CHROMATOGRAPHY COLUMN (Mistrík)
Utility Model: CZ 35118. Granted: 1.6.2021. Ownership: Palacky University, Olomouc. Inventors: Mistrík Martin, Škrott Zdeněk, Oždian Tomáš.
Status: Available
Master mentorship
Machačová Zuzana M.Sc.
The role of the p97 / NPL4 protein complex in repairing damaged DNA
Status: Graduated from 2019 to 2021.
Loffelmann Martin
Identification of new inhibitors of NPL4 protein and insight into the mechanism of their action
Status: Graduated from 2020 to 2022.
Svobodová Natálie
Targeting heat shock proteins in cancer
Status: Ongoing from 2023.
Bachelor mentorship
Soos Andrej
Crosstalk between the ubiquitin proteasome system and genome integrity
Status: Graduated from 2016 to 2017.
Kempná Magdalena
Targeting NPL4 protein in cancer
Status: Graduated from 2019 to 2020.
Open positions
1 Molecular and Translational Medicine
| Project: | Cellular stress in health and disease |
|---|---|
| Supervisors: | Mistrík Martin Ph.D., Moudrý Pavel Ph.D., Škrott Zdeněk Ph.D. |
| Available: | 3 |
| Intended for: | Doctoral training |