Voller Jiří Ph.D.
About me
Positions:
researcher (drug screening, bio-/cheminformatician)
Institute of Molecular and Translational Medicine, Faculty of Medicine & Dentistry, Palacky University
since 2011
researcher (biology of stress and aging)
Department of Experimental Biology, Faculty of Science, Palacký University
since 2022
researcher (biology of stress and aging)
Laboratory of Growth Regulators, Institute of Experimental Botany AS CR & Palacký University
2010-2022
Education:
Palacký University, Faculty of Science, Olomouc, Czech Republic
PhD - biology
Charles University - Pharmaceutical Faculty, Hradec Králové - Czech Republic
MSc - pharmacy
Masaryk University, Faculty of Science, Brno, Czech Republic
MSc - molecular biology/genetics
Research Interests:
- biology of stress and aging (human cells, C. elegans, water bears)
- circadian rhythms
- drug screening ( circadian rhythm modulators, cytoprotection, mitochondrial diseases, parasitic worms, ...)
- bio- and cheminformatics (identification of mechanism of drug action, comparison of drugs based on biological activity profiles, image analysis, machine learning)
Teaching:
Biogerontology
Drug Discovery
Biology of Circadian Rhythms and Sleep
Biology of Reproduction
Journals
Open positions
2 Medical biology
| Project: | Physiology and pathophysiology of aging |
|---|---|
| Supervisors: | Hajdúch Marián M.D., Ph.D., Voller Jiří Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Summary: | 2 places in full-time study |
| Project: | Search and characterization of substances for the therapy of congenital or acquired diseases caused by aberrant splicing of pre-mRNA |
|---|---|
| Supervisors: | Voller Jiří Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | 1 place in full-time study |
1 Biostatistics, bioinformatics and chemoinformatics
| Project: | Bio- and cheminformatics in biology of aging |
|---|---|
| Supervisors: | Voller Jiří Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | Although hundreds of biological databases are available, a richly annotated database of anti-aging compounds with diverse mechanisms of action has been missing. The aim of the project is to create a database of compounds with anti-aging activity that would offer a rich annotation of both compound and involved biological mechanisms. The data will be collected from a wide range of public databases, by text-mining of scientific literature and patents as well as from results of in-house high-throughput screening. The data will be used for formulation of new hypotheses of mechanisms of aging as well as for identification of novel anti-aging compounds. |
2 Chemical biology and experimental therapeutics
| Project: | Screening and characterization of compounds for therapy of mitochondrial and metabolic disorders |
|---|---|
| Supervisors: | Voller Jiří Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | Pharmacotherapy of hereditary mitochondrial diseases including neurodegenerations and cardiopathies is only symptomatical at present. The aim of this study is to identify the novel candidate drugs by high-throughput screening using patient-derived cell lines. The assays will evaluate survival under metabolic and oxidative stress as well as morphology and function of mitochondria. Mechanism of action of promising compounds will be studied by OMICS methods. |
| Project: | Screening and characterization of compounds for therapy of diseases caused by aberrant pre-mRNA splicing |
|---|---|
| Supervisors: | Voller Jiří Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | Recently, we identified several novel modulators of alternative splicing with the ability to increase expression of wild-type transcripts of several genes relevant for neurodegeneration or cancer. However, mechanisms of action of those promising compounds remains unclear. The aim of the project is to (i) identify molecular targets and relevant pathways, (ii) design assays for high-througput screening of a library of chemical compounds, and (iii) to identify novel structural types of active compounds. |
1 Pathophysiology and new drug targets
| Project: | Identification of pro-longevity pathways and mechanisms of model organisms |
|---|---|
| Supervisors: | Voller Jiří Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | The aim of the project is to identify the novel compounds which can increase life-span of C. elegans, increase their resistance against stress and neurodegeneration, using high-throughput and high-content screening platforms. Active compounds will be further studied in human cell cultures. Mechanisms of action of interesting hits will be studied by OMICS |
4 Molecular and Translational Medicine
| Project: | Search and study of the mechanism of action of new circadian rhythm modulators for the therapy of civilization diseases |
|---|---|
| Supervisors: | Voller Jiří Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Project: | Search and characterization of compounds for the therapy of congenital or acquired diseases caused by aberrant pre-mRNA editing |
|---|---|
| Supervisors: | Voller Jiří Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Project: | Search and study of the mechanism of action of substances affecting the viability and motility of human spermatozoa |
|---|---|
| Supervisors: | Voller Jiří Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Project: | Physiology and pathophysiology of ageing |
|---|---|
| Supervisors: | Hajdúch Marián M.D., Ph.D., Voller Jiří Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |